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KMID : 0377619870520010045
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Korean Jungang Medical Journal
1987 Volume.52 No. 1 p.45 ~ p.55
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Vitamin D Metabolism in Human Body
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Abstract
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To determine the effect of sunlight and activity to the hospitalized patients, we measured 25(OH)D (calcidiol), 1,25(OH)2D (calcitriol) and PTH values in circulating blood.
Samples were taken from 43 inpatients who had been admitted due to trauma to the orthopedics and neurosurgery of Chosun University Hospital. Samples were also taken from 27 ambulant outpatients, and the values of 3 above mentioned items were measured.
Measurements were done by means of RIA (Radioimmunoassay) in July and August 1985.
Following results were obtained.
1) Of the 43 inpatients, 18(41.9%) showed low 25(OH)D values (below 12ng/ml), among them 8 were of unmeasurable values (below 5ng/ml). Among 27 outpatients, only one (4%) showed low 25(OH)D value.
2) All but one low-25(OH)D cases showed normal 1, 25(OH)2D value.
3) On the whole, 25(OH)D values decline with age from 4th decade.
4) 1,25(OH)2D values are highest in 2nd decade. Between other decades, the average 1,25(OH)2D values are almost even.
5) PTH values are significantly higher (3.8±0.6 ng/ml vs. 2.1±0.3ng/ml, P 0.01) in low-25(OH)D group than in those of normal group.
Thus, it is supposed that lack of sunlight exerted a great deal of adverse effect to the inpatients resulting low 25(OH)D values, however so resulting hypocalcemia and a fall in ionized calcium level leads to greater PTH secretion, which in turn stimulate 1?-hydroxylase activity and consequent high 1,25(OH)2D.
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KEYWORD
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